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Endothelial dysfunction in chronic obstructive pulmonary disease.

Leo Moro1, Claudio Pedone, Simone Scarlata

  • 1Area di Geriatria, Università Campus Biomedico, Rome, Italy. l.moro@unicampus.it

Angiology
|April 5, 2008
PubMed
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Endothelial dysfunction, a marker of cardiovascular risk, is significantly impaired in chronic obstructive pulmonary disease (COPD) patients. This impairment correlates with the severity of bronchial obstruction in COPD.

Area of Science:

  • Cardiology
  • Pulmonology
  • Vascular Biology

Background:

  • Cardiovascular diseases frequently affect individuals with chronic obstructive pulmonary disease (COPD).
  • Endothelial dysfunction is investigated as a potential marker for proatherogenic status in COPD patients.

Purpose of the Study:

  • To assess endothelial function in patients with COPD.
  • To determine if endothelial dysfunction is associated with the severity of COPD.

Main Methods:

  • Flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD) were measured in 44 COPD patients and 48 controls.
  • Statistical analysis, including multiple linear regression, was used to evaluate associations.

Main Results:

  • COPD patients exhibited significantly worse FMD (5.4% vs. 8.2%) and NMD (12.0% vs. 13.9%) compared to controls.

Related Experiment Videos

  • FMD was inversely associated with the FEV1/VC ratio (r = -0.327, P = .030).
  • NMD was positively associated with FMD (beta = 0.396, P < .001) in a regression model.

    • Conclusions:

    • Both endothelial-dependent (FMD) and endothelial-independent (NMD) dilations are impaired in COPD.
    • The degree of endothelial dysfunction is proportional to the severity of bronchial obstruction in COPD.