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[Association of cardiovascular risk factors in hypertensive patients with left ventricular hypertrophy]

C Laviades1, G Mayor, J Díez

  • 1Departamento de Medicina Interna, Hospital San Jorge, Huesca.

Revista Clinica Espanola
|December 1, 1991
PubMed

Insights

Essential hypertension with left ventricular hypertrophy (LVH) increases cardiovascular risk. Patients with LVH exhibit higher blood pressure, alcohol and tobacco use, triglycerides, uric acid, and plasma renin activity, contributing to mortality.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Investigation

Background:

  • Essential hypertension is a leading cause of cardiovascular morbidity and mortality.
  • Left ventricular hypertrophy (LVH) is a significant complication of hypertension, further elevating cardiovascular risk.
  • The influence of concurrent risk factors on cardiovascular outcomes in hypertensive patients with LVH requires further elucidation.

Purpose of the Study:

  • To investigate the distribution of cardiovascular risk factors in essential hypertensive patients with and without LVH.
  • To identify factors associated with increased cardiovascular risk in hypertensive individuals with LVH.

Main Methods:

  • A cohort of 50 untreated essential hypertensive patients was divided into two groups: 32 with LVH (left ventricular mass index > 120 g/m²) and 18 without LVH, diagnosed via echocardiography.
  • Cardiovascular risk factors including blood pressure, alcohol and tobacco consumption, lipid profile, uric acid, plasma renin activity, and other lifestyle factors were assessed and compared between the groups.

Main Results:

  • Patients with LVH demonstrated significantly higher systolic and mean arterial pressures, alcohol and tobacco consumption, triglyceride levels, uric acid levels, and plasma renin activity compared to those without LVH.
  • Plasma cholesterol levels were also elevated in the LVH group, exceeding the normal limit and indicating increased cardiovascular risk.
  • Factors such as age, sex, diastolic blood pressure, sedentary lifestyle, and carbohydrate intolerance did not differ significantly between the groups.

Conclusions:

  • Hypertensive patients with LVH present with a constellation of additional risk factors beyond ventricular hypertrophy itself.
  • These concurrent risk factors contribute to the elevated cardiovascular morbidity and mortality observed in the LVH group.
  • Targeting these additional risk factors may be crucial for mitigating cardiovascular complications in essential hypertensive patients with LVH.

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