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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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A Rat Model of Compound Acne
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Familial dyskeratotic comedones.

M Sendhil Kumaran1, Divya Appachu, Elizabeth Jayaseelan

  • 1Department of Dermatology, St. Johns Medical College Hospital, Bangalore, India. drsen_2000@yahoo.com

Indian Journal of Dermatology, Venereology and Leprology
|April 5, 2008
PubMed
Summary
This summary is machine-generated.

Familial dyskeratotic comedones (FDC) is a rare genetic skin condition causing widespread comedone-like papules. This report details two cases, highlighting the disorder

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Area of Science:

  • Dermatology
  • Genetics
  • Histopathology

Background:

  • Familial dyskeratotic comedones (FDC) is a rare autosomal dominant inherited disorder.
  • Characterized by widespread, symmetrical, comedone-like, hyperkeratotic papules.
  • Lesions typically appear around puberty and worsen over time.

Observation:

  • The reported cases presented with a strong family history of FDC.
  • Lesions were cosmetically unappealing, asymptomatic, and predominantly affected the trunk, arms, and face.
  • Histological examination revealed epidermal invagination with a lamellar keratinous plug and focal dyskeratosis.

Findings:

  • Two cases of familial dyskeratotic comedones with significant familial history are presented.
  • The characteristic clinical and histological features of FDC were observed.
  • The condition's typical refractoriness to treatment was noted.

Implications:

  • This report contributes to the understanding of a rare genetic dermatosis.
  • Highlights the importance of family history in diagnosing FDC.
  • Further research may explore potential therapeutic strategies for this refractory condition.