Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Myasthenia Gravis ll: Pathophysiology

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Apremilast: A Novel and Effective Therapy for Pityriasis Lichenoides Chronica.

Indian dermatology online journal·2026

Same author

Topical Cetirizine in Androgenetic Alopecia: A Preliminary Study.

Skin appendage disorders·2026

Same author

Pseudorheumatoid nodules in a young woman.

Indian journal of dermatology, venereology and leprology·2025

Same author

Acquired port-wine stain: a case report and differential diagnosis.

BMJ case reports·2024

Same author

Systemic tofacitinib in paediatric alopecia areata.

Indian journal of dermatology, venereology and leprology·2024

Same author

A Rare Case of Disseminated Histoplasmosis in an Immunocompetent Girl.

Indian dermatology online journal·2024

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Childhood sclerodermatomyositis with generalized morphea.

Girishkumar R Ambade¹, Rachita S Dhurat, Nitin Lade

¹Department of Dermatology, LTM Medical College and LTM General Hospital, Mumbai, India.

Indian Journal of Dermatology, Venereology and Leprology

|April 5, 2008

Summary

This case study details an 11-year-old girl with juvenile systemic sclerosis (JSS) who later developed juvenile dermatomyositis (JDM). The patient was diagnosed with sclerodermatomyositis (SDM) due to overlapping features.

Related Experiment Videos

Last Updated: Jul 6, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Area of Science:

Rheumatology
Pediatric Rheumatology
Immunology

Background:

Systemic sclerosis (SS) and dermatomyositis (DM) are multisystem autoimmune disorders with overlapping clinical manifestations.
Distinguishing between these conditions, particularly in pediatric cases, can be challenging.

Observation:

An 11-year-old girl initially presented with features of juvenile systemic sclerosis (JSS).
Her condition evolved, exhibiting a changing clinical pattern suggestive of slowly progressing juvenile dermatomyositis (JDM).
The patient also had associated generalized morphea.

Findings:

Serological tests revealed antinuclear antibodies (ANA) with a speckled pattern; specific antibodies like Topoisomerase-I (Scl-70) and anti-Jo-1 were negative.
Electromyography (EMG) indicated a primary muscle disease, while histopathology confirmed scleroderma.
The patient met diagnostic criteria for both JSS and JDM separately, leading to a diagnosis of sclerodermatomyositis (SDM).
Immunological studies excluded mixed connective tissue disease (MCTD) and antisynthetase antibody syndrome (ASS).

Implications:

This case highlights the diagnostic complexity of overlapping autoimmune conditions in children.
Recognizing evolving clinical patterns is crucial for accurate diagnosis and management of pediatric rheumatic diseases.
Sclerodermatomyositis (SDM) represents a distinct entity requiring tailored therapeutic strategies.