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Subcutaneous panniculitis-like T-cell cutaneous lymphoma
Avninder Singh1, Joginder Kumar, Sujala Kapur
1Institute of Pathology (ICMR), New Delhi, India. dravninder@yahoo.co.in
Indian Journal of Dermatology, Venereology and Leprology
|April 5, 2008
Summary
Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare condition presenting as skin nodules. This case study shows successful treatment of SPTCL with the CHOP regimen, leading to lesion regression.
Area of Science:
- Hematology
- Dermatology
- Oncology
Background:
- Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cytotoxic T-cell lymphoma.
- It is classified as a unique extranodal lymphoma with characteristic T cell receptor (TCR) gene rearrangement.
Observation:
- A 22-year-old woman presented with multiple, variable-sized nodules on her legs.
- Differential diagnoses included panniculitis and lupus panniculitis.
- Histopathology revealed a subcutaneous lobular infiltrate with atypical lymphocytes and adipocyte rimming.
Findings:
- Immunohistochemistry showed a CD4-, CD8+, CD56- T-cell phenotype.
- The findings suggested a possible SPTCL alpha/beta type, despite the absence of TCR rearrangement studies.
- The patient's skin lesions and constitutional symptoms regressed after five cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy.
Implications:
- This case highlights the importance of considering SPTCL in the differential diagnosis of subcutaneous nodules.
- The successful use of the CHOP regimen in this patient suggests its potential efficacy for SPTCL.
- Further research into SPTCL diagnosis and treatment is warranted.
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