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Polypoid eosinophilic cystitis with pseudosarcomatous proliferative tissue in a dog
Kiyokazu Ozaki1, Yutaka Nakahara, Isao Narama
1Department of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Hirakata, Osaka, Japan. ozaki@pharm.setsunan.ac.jp
The Journal of Veterinary Medical Science
|April 5, 2008
Summary
A dog with hematuria had two urinary bladder masses diagnosed as eosinophilic polypoid cystitis. This condition showed pseudosarcomatous features with varied cell types and low growth activity.
Area of Science:
- Veterinary Pathology
- Canine Urology
Background:
- Urinary bladder masses in dogs can present with varied clinical signs, including hematuria.
- Accurate histopathological diagnosis is crucial for differentiating benign conditions from neoplastic processes.
Observation:
- Two small polypoid masses were identified in the urinary bladder mucosa/submucosa of a dog presenting with hematuria.
- Histological examination revealed a proliferation of spindle-shaped, round, and pleomorphic cells with atypical nuclei and eosinophil infiltration.
Findings:
- Immunohistochemical staining confirmed the presence of fibroblasts, myofibroblasts, and macrophages within the masses.
- The masses were characterized by a diverse cell population and rare mitotic figures, leading to a diagnosis of eosinophilic polypoid cystitis with pseudosarcomatous proliferative tissue.
- The low growth activity and specific cellular composition were key diagnostic factors.
Implications:
- This case highlights the importance of thorough histopathological and immunohistochemical analysis for diagnosing unusual bladder conditions in dogs.
- Understanding pseudosarcomatous changes in benign conditions like eosinophilic polypoid cystitis is vital for appropriate clinical management and prognosis.
- The findings contribute to the veterinary literature on non-neoplastic urinary bladder masses in companion animals.
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