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[Effect of sotalol on left ventricular mass and function in the hypertensive patient]
P Gosse1, P Durandet, R Roudaut
1CHU de Bordeaux, hôpital cardiologique, Pessac.
Insights
Sotalol treatment significantly reduced blood pressure and heart rate in patients with essential hypertension and left ventricular hypertrophy. It also decreased left ventricular mass, improving filling patterns without affecting systolic function.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Essential hypertension often coexists with left ventricular hypertrophy.
- Left ventricular hypertrophy can impair diastolic function.
Purpose:
- To evaluate the effects of Sotalol on blood pressure, left ventricular mass, and function in hypertensive patients with left ventricular hypertrophy.
Summary:
- Six months of Sotalol treatment in 26 patients with essential hypertension and left ventricular hypertrophy led to significant reductions in blood pressure and heart rate.
- Left ventricular mass index decreased by 8% (p < 0.001), primarily due to reduced wall thickness.
- Left ventricular systolic function remained unchanged, while diastolic function improved, indicated by an increased E/A ratio.
Impact:
- Sotalol effectively manages blood pressure and reduces cardiac remodeling in hypertensive patients with left ventricular hypertrophy.
- The findings suggest Sotalol may offer benefits beyond heart rate control in this patient population.
Abstract:
The effects of 6 months treatment with Sotalol on the blood pressure, left ventricular mass and function, were studied in patients with essential hypertension and left ventricular hypertrophy. Thirty-three patients (18 men and 15 women aged 53 +/- 11 years) were included initially and 26 were reviewed after 6 months of treatment. The left ventricular mass and function were evaluated by Doppler echocardiography and all recordings were interpreted "blind" at the end of the study by two operators. Treatment led to a significant reduction of the blood pressure (152 +/- 12/94 +/- 11 versus 166 +/- 18/100 +/- 9 mmHg) and of the heart rate (60 +/- 10 versus 76 +/- 12 beats per minute). The left ventricular mass index decreased by 8% (p less than 0.001) due to reduction in wall thickness. Resting left ventricular systolic function was unchanged. Left ventricular filling patterns improved with an increase in the E/A ratio which was reduced at the beginning of the trial.