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Related Experiment Videos

Computer-assisted glucose control in critically ill patients.

Mathijs Vogelzang1, Bert G Loef, Joost G Regtien

  • 1Department of Critical Care, University Medical Center, University of Groningen, 9700 RB, Groningen, The Netherlands. m.vogelzang@thorax.umcg.nl

Intensive Care Medicine
|April 5, 2008
PubMed
Summary
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This study shows that a computer-assisted glucose control protocol (GRIP) safely and efficiently manages blood sugar in critically ill patients. It achieved target glucose levels with fewer measurements and low hypoglycemia rates.

Area of Science:

  • Critical Care Medicine
  • Endocrinology
  • Medical Informatics

Background:

  • Intensive insulin therapy in critically ill patients carries risks of hypoglycemia and high costs.
  • Computer-assisted glucose control offers a potential solution to optimize glycemic management.

Purpose of the Study:

  • To evaluate the safety and efficiency of the Glucose Regulation for Intensive Care Patients (GRIP) protocol.
  • To assess the impact of a computer-assisted glucose control protocol on hypoglycemia rates and resource utilization.

Main Methods:

  • An observational cohort study was conducted in three intensive care units (ICUs) of a university teaching hospital.
  • The study included 2,800 patients across surgical, neurosurgical, and cardiothoracic units, implementing the GRIP protocol.

Related Experiment Videos

  • Compliance with insulin pump rates and glucose measurement frequency was analyzed.

    • Main Results:

    • Patients adhered to GRIP-ordered pump rates 97% of the time.
    • Hypoglycemia was infrequent: 7% mild (< 3.5 mmol/l) and 0.86% severe (< 2.2 mmol/l).
    • The target glucose range (4.0-7.5 mmol/l) was achieved within 5.6 hours and maintained for 89% of the ICU stay, using an average of 5.9 measurements per patient daily.

    Conclusions:

    • The GRIP computer-assisted glucose control protocol is safe and effective for routine intensive care.
    • This protocol achieves glycemic targets with a low incidence of hypoglycemia and reduced glucose monitoring frequency compared to other methods.