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Updated: Jul 6, 2026
Murine Renal Transplantation Procedure
Published on: July 10, 2009
Outcome after renal transplantation. Part I: intellectual and motor performance
Jutta Falger1, Bea Latal, Markus A Landolt
1Nephrology Unit, University Children's Hospital, Steinwiesstrasse 75, Zurich, Switzerland.
Insights
Children and adolescents with chronic kidney disease show normal intellectual performance (IP) post-renal transplantation (RTPL), but have lower performance IQ and significantly affected motor performance (MP).
Area of Science:
- Pediatric Nephrology
- Neurodevelopmental Outcomes
- Chronic Kidney Disease
Background:
- Neurodevelopmental outcomes in pediatric chronic kidney disease (CKD) patients are not well-documented.
- Information on intellectual performance (IP) and motor performance (MP) after renal transplantation (RTPL) is limited.
Purpose of the Study:
- To systematically assess intellectual and motor performance in children and adolescents following renal transplantation.
- To identify factors influencing neurodevelopmental outcomes in this patient population.
Main Methods:
- Assessed 27 pediatric patients post-RTPL using the Wechsler Intelligence Scale for Children-III (WISC-III) and Kaufman Assessment Battery for Children for IP.
- Evaluated MP using the Zurich Neuromotor Assessment.
- Compared patient performance with control groups and analyzed correlations with neurological comorbidity and socioeconomic status.
Main Results:
- Median full-scale IQ (FSIQ) was 97; 21/27 patients had FSIQ ≥ 85.
- Verbal IQ (VIQ) was significantly higher than Performance IQ (PIQ) (p < 0.01).
- PIQ and all MP tasks were significantly lower compared to controls (p < 0.007 for PIQ, p < 0.01 for MP).
- Neurological comorbidity was associated with lower FSIQ (median 81).
- Socioeconomic status correlated with FSIQ (p = 0.03).
Conclusions:
- Most children and adolescents achieve normal intellectual performance post-RTPL.
- Performance IQ is lower than Verbal IQ, and motor performance is significantly impaired in all patients.
- Further research is needed to understand and address the specific neurodevelopmental deficits observed post-RTPL in pediatric CKD patients.
Abstract:
Comprehensive information on neurodevelopmental outcome in children and adolescents with chronic kidney disease is still limited. Intellectual performance (IP) and motor performance (MP) were systematically assessed in 27 patients at a median age of 14.1 years (range 6.5-17) and 6 years (range 0.5-12.7) after renal transplantation (RTPL). IP was analyzed with the Wechsler Intelligence Scale for Children-III (WISC-III) in 25 patients and by the Kaufman Assessment Battery for Children in two patients. MP was evaluated by the Zurich Neuromotor Assessment. Median full- scale intelligent quotient (FSIQ) was 97 (range 49-133). Twenty-one patients had an FSIQ >or= 85 (i.e. >or= mean-1 standard deviation). The five patients with neurological comorbidity had a median FSIQ of 81 (range 49-101). Verbal IQ (VIQ) (median 104; range 50-146) was significantly (p < 0.01) higher than performance IQ (PIQ) (median 88; range 48-117). The PIQ was significantly lower compared with controls (p < 0.007), and patients scored significantly lower compared with controls in five of 11 subtests of the Wechsler Scale. All MP tasks were significantly (p < 0.01) lower than in controls, and also in children without neurological comorbidity. Socioeconomic status was significantly correlated with FSIQ (p = 0.03). IP after RTPL was within the normal range for the majority of children. PIQ was lower compared with VIQ, and MP was significantly affected in all children after RTPL.
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