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[Difficulties in the treatment of pulmonary tuberculosis in children]

Nicoleta Brînză1, Tr Mihăescu

  • 1Spitalul Clinic de Pneumologie, Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|April 9, 2008
PubMed

Insights

Pediatric pulmonary tuberculosis management in Romania requires careful consideration of drug regimens and side effects. Treatment success rates vary, highlighting the need for individualized approaches in complex cases like HIV/AIDS comorbidities.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Public Health

Context:

  • The management of pediatric pulmonary tuberculosis in Romania follows international guidelines (ERS, WHO, IUATLD).
  • The Iaşi region has been involved in a pilot study since 1998.
  • This study retrospectively analyzed 254 children treated between 2000 and 2005.

Purpose:

  • To evaluate the treatment course, drug side effects, and outcomes of pediatric pulmonary tuberculosis in the Iaşi area.
  • To assess the effectiveness of different antitubercular drug regimens.
  • To identify challenges and factors influencing treatment success in children.

Summary:

  • A retrospective analysis of 254 children with pulmonary tuberculosis revealed that most were new cases (98.8%).
  • Treatment regimens included four-drug (47.2%), three-drug (46.9%), and individualized (5.9%) approaches, with ethambutol frequently used.
  • Side effects, primarily toxic hepatitis (2.5%), occurred in 4.1% of cases. Treatment completion was 70.5%, with a cure rate of 23.6%.
  • Complex cases involving HIV/AIDS and multidrug-resistant tuberculosis required extended treatment with fluoroquinolones.

Impact:

  • Treatment outcomes indicate a need for optimized pediatric tuberculosis management strategies.
  • Understanding drug side effects is crucial for improving patient adherence and treatment success.
  • Individualized treatment plans are essential for children with comorbidities like HIV/AIDS and hepatitis B.
Abstract

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