Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...

Matrix-Assisted Laser Desorption Ionization (MALDI)

Matrix-Assisted Laser Desorption Ionization (MALDI)

Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI is an ionization technique, widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026

Same author

From genes to generations: genetic evaluation and counseling for infertility and pregnancy loss.

Frontiers in genetics·2026

Same author

Competing forms of protein-protein association and DNA binding exhibited by BrxC from the BREX phage restriction system.

bioRxiv : the preprint server for biology·2026

Same author

Phenotypic Variability Associated with Jagunal Homolog 1 (JAGN1) Deficiency Caused by the c.63G>T Variant.

International journal of molecular sciences·2026

Same author

Snapshot Look at Castleman Disease.

Journal of cellular and molecular medicine·2026

Same author

The <i>CTDP1</i> Founder Variant in CCFDN: Insights into Pathogenesis, Phenotypic Spectrum and Therapeutic Approaches.

International journal of molecular sciences·2026

Same journal

Antioxidant Activity of Essential Oil From Carum Carvi L. Cultivated in North-Eastern Romania.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Assessment of In Vitro Antioxidant activity of Some New Ferulic Acid Derivatives.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Fast RP-HPLC Method for the Determination of Bisoprolol.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

In Vitro Dissolution Studies of Amiodarone Hydrochloride From Hydroxy-Propyl-β-Cyclodextrin/Amiodarone Inclusion Complex Formulated Into Modified-Release Tablets.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Esthetic Rehabilitation Through CAD/CAM Technology - Case Report.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

Same journal

Correlation Among Chronological Age, Dental Age and Cervical Vertebrae Maturity in Romanian Subjects.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi·2018

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Published on: February 20, 2015

[MLPA technique--principles and use in practice].

Cristina Rusu¹, Adriana Sireteanu, Maria Puiu

¹Disciplina de Genetică Medicală, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa", Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi

|April 9, 2008

Summary

This summary is machine-generated.

Multiplex Ligation-dependent Probe Amplification (MLPA) is a simple, reliable, and affordable PCR-based technique for detecting various genetic abnormalities. This method offers significant advantages for modern genetic testing services.

Related Experiment Videos

Last Updated: Jul 6, 2026

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Published on: February 20, 2015

Area of Science:

Molecular Biology
Genetics
Biotechnology

Context:

Multiplex Ligation-dependent Probe Amplification (MLPA) is a novel technique.
MLPA is based on the Polymerase Chain Reaction (PCR) principle.
It is used for detecting genetic abnormalities.

Purpose:

To present MLPA as a valuable method for genetic services.
To highlight the advantages of MLPA.
To discuss the importance of MLPA in modern genetic diagnostics.

Summary:

MLPA enables the detection of various genetic abnormalities including aneuploidies, gene deletions/duplications, subtelomeric rearrangements, and methylation status.
The technique is characterized by its simplicity, reliability, and cost-effectiveness.
This method is presented as a significant advancement in genetic analysis.

Impact:

MLPA offers a versatile and efficient tool for genetic laboratories.
The technique's advantages contribute to improved diagnostic capabilities.
It supports the advancement of personalized medicine through precise genetic analysis.