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Effects of Ocimum basilicum L. extract on experimental acute inflammation
Daniela Benedec1, Alina Elena Pârvu, Ilioara Oniga
1Department of Pharmacognosy, School of Pharmacy, "I. Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca.
Unlabelled:
Our study investigated the effects of Ocimum basilicum L. tincture (1:10) in acute inflammation induced with turpentine oil (i.m. 0.6 ml/100 g b.w.) in Wistar male rats.
Material And Methods:
The results were compared with those from a positive control group with experimental inflammation and a group treated with diclofenac (30 mg/100 g b.w.). The effects were assessed by measuring total leukocyte count and differential leukocyte count expressed as a percentage, a test of in vitro phagocytosis, and the evaluation of nitric oxide synthesis by measuring the metabolites, nitrites and nitrates, and the co-product citrulline.
Results:
Ocimum basilicum tincture significantly reduced the total leukocyte count, monocyte percentage, activation of circulating phagocytes, but had a slight inhibitory effect on NO synthesis. Compared to diclofenac, Ocimum basilicum tincture had a smaller inhibitory effect on all tested parameters.
Conclusion:
The tested Ocimum basilicum tincture has important anti-inflammatory effects on bone marrow acute phase response and a reduced one on NO synthesis.
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