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Updated: Jul 6, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
Published on: October 14, 2025
[Advances in biologic therapy for inflammatory bowel disease]
Raffaello Sostegni1, Angelo Pera, Marco Daperno
1Unità Operativa Autonoma Gastroenterologia, Azienda Ospedaliera Ordine Mauriziano, Torino.
Biologic agents have revolutionized inflammatory bowel disease treatment, showing significant efficacy in managing moderate to severe Crohn
Area of Science:
- Gastroenterology and Immunology
- Pharmacology
Context:
- Inflammatory bowel disease (IBD) management has evolved.
- Biologic therapies represent a significant advancement.
Purpose:
- To critically evaluate controlled studies on biologic agents for IBD.
- To assess the efficacy of biologics in Crohn's disease and ulcerative colitis.
Summary:
- Biologic agents have transformed IBD treatment.
- Controlled studies demonstrate their efficacy in moderate to severe cases.
- This review critically analyzes these findings.
Impact:
- Biologics offer a major therapeutic advance for IBD patients.
- Improved management strategies for Crohn's disease and ulcerative colitis.
- Highlights the critical role of biologics in modern gastroenterology.
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