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Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population
J Morikawa1, S Yoshida, S Kennedy
1Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Purpose:
To investigate a possible association between uterine leiomyomas and catechol-O-methyltransferase (COMT) polymorphisms in a Japanese population.
Methods:
We compared the allele frequencies and genotype distributions of the exon 4 NlaIII restriction site polymorphism (RSP), the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP in the COMT gene in 250 leiomyoma cases and 182 controls using polymerase chain reaction-restriction fragment-length polymorphism analysis.
Results:
No significant differences in allele frequencies and genotype distributions of the exon 4 NlaIII RSP, the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP were found between uterine leiomyoma cases and controls. Moreover, no associations were noted between these three polymorphisms in COMT genes and leiomyoma size or a family history of uterine leiomyomas.
Conclusion:
COMT gene polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in a Japanese population.
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