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[Inhibitive effect of local perfusion of tanshinone II A nanoparticles on MMP-2 secretion]
Ling Liang1, Wei-Hua Li, Rong Wu
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To test the effect of Tanshinone II A nanoparticles on the expression of MMP-2.
Methods:
Thirty five male New Zealand white rabbits were randomly divided into three groups. In group A (15 rabbits), the carotid arteries of the rabbits were stripped. In group B (5 rabbits) and C (15 rabbits), nanoparticles and Tanshinone II A nanoparticles were perfused respectively in the denudated arteries of the rabbits. The neointimal areas and the IOD values of MMP-2 secretion were measured.
Results:
A significant reduction of neointimal hyperplasia in group C was found compared to the other two groups in terms of the intimal area and the intima-media ratio. Group C had significant lower IOD values than group A.
Conclusion:
Local administration of nanoparticles with incorporated Tanshinone I A not only inhibits neointimal hyperplasia but also inhibits the expression of MMP-2 in stripped arteries.