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Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

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Anatomical optical coherence tomography for long-term, portable, quantitative endoscopy.

Matthew S Leigh¹, Julian J Armstrong, Alexandre Paduch

¹Optical+Biomedical Engineering Laboratory (OBEL), School of Electrical, Electronic & Computer Engineering, University of Western Australia, Crawley, W.A. 6009, Australia. mleigh@eeuwa.edu.au

IEEE Transactions on Bio-Medical Engineering

|April 9, 2008

Summary

Anatomical optical coherence tomography offers safe, quantitative imaging of internal anatomy. This new catheter-based tool can monitor airway changes during sleep for obstructive sleep apnea (OSA) diagnosis.

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Published on: August 4, 2018

Area of Science:

Medical Imaging
Biomedical Engineering
Ophthalmology

Background:

Current imaging modalities for internal hollow organs have limitations.
Characterizing obstructive sleep apnea (OSA) requires detailed upper airway assessment.
Extended observational periods for internal anatomy imaging are often challenging.

Purpose of the Study:

To introduce anatomical optical coherence tomography (aOCT) as a novel catheter-based imaging technique.
To describe the design and performance of an aOCT instrument.
To evaluate the initial application of aOCT in the human upper airway for OSA characterization.

Main Methods:

Development of a catheter-based optical coherence tomography system.
Quantitative sectional imaging of internal hollow organ anatomy.
In-vivo imaging of human subjects during sleep.

Main Results:

The aOCT instrument successfully provided quantitative sectional images of the upper airway.
The system demonstrated capability for imaging subjects during sleep.
Dynamic changes in airway size and shape were recorded, relevant for OSA.

Conclusions:

Anatomical optical coherence tomography is a safe, quantitative imaging modality for extended use.
The developed instrument is suitable for bedside operation and long-term monitoring.
aOCT shows significant potential for characterizing the upper airway in conditions like OSA.