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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
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Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

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Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

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Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
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New frontiers in pediatric oncologic imaging.

M Beth McCarville1

  • 1St. Jude Children's Research Hospital, Memphis, TN 38105, USA. beth.mccarville@stjude.org

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
|April 9, 2008
PubMed
Summary

New imaging techniques offer objective tumor assessment for pediatric cancer patients. These advanced methods, including MRI and PET-CT, provide earlier insights into treatment effectiveness in children.

Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Traditional tumor size measurement may not accurately reflect treatment-induced changes in tumor viability.
  • Oncologists and radiologists require objective methods to assess tumor metabolism and blood flow for earlier treatment response evaluation.
  • Pediatric imaging faces unique challenges, including sedation needs and long-term radiation effects in growing children.

Purpose of the Study:

  • To discuss the evolving role of advanced imaging in assessing pediatric cancer treatment response.
  • To explore novel imaging techniques for monitoring therapeutic effects in pediatric oncology.
  • To evaluate the potential benefits and limitations of new imaging modalities in children undergoing cancer therapy.

Main Methods:

  • Investigating dynamic enhanced magnetic resonance imaging (dMRI) and quantitative contrast-enhanced ultrasonography (qCEUS) for assessing tumor blood flow in pediatric solid tumors like osteosarcoma and neuroblastoma.

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  • Utilizing nuclear imaging, including positron emission tomography-computed tomography (PET-CT), for evaluating pediatric musculoskeletal tumors and neuroblastoma.
  • Discussing the application of these advanced imaging techniques in the context of pediatric cancer treatment monitoring.

    • Main Results:

    • Advanced imaging techniques show promise in providing objective measures of tumor response beyond size.
    • Dynamic enhanced MRI and qCEUS can assess tumor vascularity, offering insights into treatment efficacy.
    • Nuclear imaging, such as PET-CT, aids in evaluating metabolic activity and treatment response in pediatric tumors.

    Conclusions:

    • New imaging technologies offer a paradigm shift in evaluating anticancer treatment response in pediatric oncology.
    • Advanced imaging methods provide earlier and more accurate information on tumor viability and treatment effects compared to traditional methods.
    • Careful consideration of risks and benefits is crucial when implementing novel imaging approaches for children undergoing cancer therapy.