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Updated: Jul 6, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
Published on: March 7, 2018
Ca2+-operated transcriptional networks: molecular mechanisms and in vivo models
Britt Mellström1, Magali Savignac, Rosa Gomez-Villafuertes
1Centro Nacional de Biotecnología, Consejo Superior Investigaciones Científicas, Madrid, Spain.
Abstract:
Calcium is the most universal signal used by living organisms to convey information to many different cellular processes. In this review we present well-known and recently identified proteins that sense and decode the calcium signal and are key elements in the nucleus to regulate the activity of various transcriptional networks. When possible, the review also presents in vivo models in which the genes encoding these calcium sensors-transducers have been modified, to emphasize the critical role of these Ca(2+)-operated mechanisms in many physiological functions.
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