Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Moss-derived</i> recombinant Factor H, CPV-104, effectively antagonizes alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy.

Frontiers in immunology·2026
Same author

Hypoimmunogenic iPSC-derived hepatic organoids featuring a functional vascular network.

Scientific reports·2026
Same author

Complement-Mediated Postpartum Atypical Hemolytic Uremic Syndrome With Collapsing Focal Segmental Glomerulosclerosis Associated With a Novel CFHR5 Copy Number Variant.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Anti-nephrin antibodies are not enriched in patients with primary and posttransplant recurrent podocytopathies.

The Journal of clinical investigation·2026
Same author

Response to the Letter to the Editor Entitled "Defining "Dominance" in Atypical Hemolytic Uremic Syndrome: Distinguishing Amplification From Initiation".

Kidney international reports·2026
Same author

Molecular determinants of STEC-HUS: from complement activation to microvascular thrombosis.

Frontiers in immunology·2026

Related Experiment Video

Updated: Jul 6, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Allograft rejection: acute and chronic studies.

Susanna Tomasoni1, Giuseppe Remuzzi, Ariela Benigni

  • 1Mario Negri Institute for Pharmacological Research, Ospedali Riuniti di Bergamo, Bergamo, Italy.

Contributions to Nephrology
|April 9, 2008
PubMed
Summary

Gene therapy offers a promising approach to reduce organ transplant rejection and minimize the need for long-term immunosuppressive drugs, thereby decreasing risks of infection and cancer. This review explores experimental gene therapy applications in organ allotransplantation to combat acute and chronic rejection.

Related Experiment Videos

Last Updated: Jul 6, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Area of Science:

  • Immunology
  • Transplantation Biology
  • Molecular Medicine

Background:

  • Organ transplantation is crucial for end-stage renal disease but relies on immunosuppressants with significant side effects like infections, cancer, and nephrotoxicity.
  • Current immunosuppressive regimens, while effective against acute rejection, contribute to long-term graft loss via chronic allograft nephropathy.
  • Reducing early graft insults is key to improving long-term transplant functionality.

Purpose of the Study:

  • To review gene therapy strategies for overcoming acute and chronic rejection in experimental organ/tissue allotransplantation.
  • To explore the potential of gene therapy in reducing or eliminating the need for long-term immunosuppressive drug administration.
  • To highlight the application of gene therapy in mitigating the adverse effects associated with conventional immunosuppression.

Main Methods:

  • Review of experimental gene therapy studies in organ/tissue allotransplantation models.
  • Analysis of gene transfer techniques encoding immunomodulatory proteins.
  • Evaluation of therapeutic outcomes in preventing or managing graft rejection.

Main Results:

  • Gene therapy has emerged as a viable strategy in experimental organ transplantation over the past decade.
  • Transferring genes for immunomodulatory proteins shows potential in managing graft rejection.
  • Gene therapy aims to reduce reliance on conventional immunosuppressive drugs and their associated toxicities.

Conclusions:

  • Gene therapy presents a promising therapeutic avenue to improve outcomes in organ transplantation.
  • It offers a potential alternative to lifelong immunosuppression, thereby reducing patient morbidity.
  • Further research in experimental models is essential to translate gene therapy into clinical practice for organ allotransplantation.