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Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide

Published on: August 4, 2023

Reference materials and commutability.

Hubert W Vesper¹, W Gregory Miller, Gary L Myers

¹Centers for Disease Control and Prevention, Division of Laboratory Sciences, Atlanta, GA 30341, USA. HVesper@cdc.gov

The Clinical Biochemist. Reviews

|April 9, 2008

Summary

This summary is machine-generated.

Commutability of reference materials is vital for accurate clinical chemistry measurements. This review details experimental methods to assess this critical property, ensuring reliable patient care.

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Area of Science:

Clinical Chemistry
Laboratory Medicine
Reference Materials

Background:

Accurate laboratory measurements are essential for patient care and disease management.
Standardization and traceability to reference systems ensure reliable results across time and location.
Reference materials are crucial for establishing traceability and are key components of reference systems.

Purpose of the Study:

To explain the importance of reference material commutability in clinical chemistry.
To review experimental approaches for assessing commutability.
To highlight the significance of commutability for measurement procedures used directly on patient samples.

Main Methods:

The review synthesizes literature on experimental designs for assessing commutability.
Focuses on methods relevant to measurement procedures optimized for direct patient sample analysis.
Discusses the procedure-specific nature of commutability assessment.

Main Results:

Commutability ensures reference materials behave like patient samples across different measurement procedures.
Assessing commutability requires specific experimental designs.
This property is critical for the appropriate use of reference materials in clinical assays.

Conclusions:

Commutability is a critical property of reference materials for ensuring the validity of clinical laboratory measurements.
Understanding and assessing commutability is essential for reliable patient diagnosis and management.
The review provides a summary of methods to evaluate this key characteristic.