Domino liver transplantation

Area of Science:

• Hepatology
• Transplant Surgery
• Medical Ethics

Background:

• End-stage liver disease necessitates transplantation, but donor organ scarcity leads to long waiting lists and mortality.
• Living donor liver transplantation increases graft availability.
• Domino liver transplantation (DLT) utilizes explanted native livers from recipients with metabolic disorders as grafts.

Purpose of the Study:

• To review the global status of domino liver transplantation (DLT).
• To present updated results from the Domino Liver World Transplant Register (DLTR).
• To share experience with DLT at Karolinska University Hospital Huddinge.

Main Methods:

• Review of global DLT procedures.
• Analysis of data from the Domino Liver World Transplant Register (DLTR).
• Presentation of case series from Karolinska University Hospital Huddinge.

Main Results:

• DLT is a viable strategy to increase liver graft supply.
• Updated DLTR data and Karolinska University Hospital Huddinge experience demonstrate feasibility and outcomes.
• Patients with specific metabolic disorders are suitable candidates for DLT.

Conclusions:

• Domino liver transplantation is an established and effective strategy to address donor organ shortages.
• DLT expands the donor pool by utilizing otherwise discarded organs.
• Careful patient selection is crucial for successful domino liver transplantation.