Related Experiment Video
Updated: Jul 6, 2026
07:17
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
Resected xanthogranulomatous pancreatitis.
Yasuo Shima1, Yuichi Saisaka, Yoshihito Furukita
1Division of Gastroenterological Surgery, Kochi Health Sciences Center, 2125-1 Ike, Kochi 781-8555, Japan.
Journal of Hepato-Biliary-Pancreatic Surgery
|April 9, 2008
Summary
Xanthogranulomatous pancreatitis is a rare pancreatic condition. This case highlights its presentation and diagnosis in a 66-year-old man with epigastralgia.
Area of Science:
- Gastroenterology
- Pathology
- Radiology
Background:
- Xanthogranulomatous changes in the pancreas are exceptionally rare.
- Pancreatic masses can present diagnostic challenges, mimicking other malignancies.
Observation:
- A 66-year-old male presented with a two-year history of epigastric pain.
- Imaging revealed a 4-cm low-density pancreatic body mass with specific MRI signal characteristics (hyperintense T2, isointense T1).
Findings:
- Histopathological examination showed foamy histiocytes, lymphocytes, and plasma cells, indicative of xanthogranulomatous inflammation.
- Surrounding pancreatic tissue exhibited fibrosis and chronic inflammation.
- The final diagnosis was xanthogranulomatous pancreatitis, initially suspected as invasive ductal carcinoma.
Implications:
- This case underscores the importance of considering rare inflammatory conditions in pancreatic mass diagnosis.
- Accurate histopathological analysis is crucial for differentiating xanthogranulomatous pancreatitis from pancreatic cancer.
- Understanding imaging features aids in the diagnostic workup of pancreatic lesions.
Related Concept Videos
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
01:30Acute Pancreatitis II: Clinical Manifestations and Management
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
01:29Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment: