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Updated: Jul 6, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

Idiopathic collapsing glomerulopathy in children.

Ashima Gulati¹, Alok Sharma², Pankaj Hari¹

¹Department of Pediatrics, All India Institute of Medical Sciences, Teaching block, Room number 3053#, Ansari Nagar, New Delhi, 110029, India.

Clinical and Experimental Nephrology

|April 9, 2008

Summary

Idiopathic collapsing glomerulopathy (CG) in children presents as steroid-resistant nephrotic syndrome. While immunosuppressive therapy shows some benefit, two of six patients progressed to end-stage renal disease, highlighting CG

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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

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Last Updated: Jul 6, 2026

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Area of Science:

Nephrology
Pediatric Nephrology
Glomerular Diseases

Background:

Collapsing glomerulopathy (CG) is a distinct variant of focal segmental glomerulosclerosis (FSGS).
CG lesions are associated with HIV infection but are increasingly recognized in non-HIV cases.
Idiopathic CG in children warrants further clinical investigation.

Purpose of the Study:

To evaluate the clinical presentation and outcomes of pediatric patients with idiopathic collapsing glomerulopathy.
To assess the efficacy of immunosuppressive therapy in this cohort.
To identify risk factors for end-stage renal disease (ESRD) in pediatric idiopathic CG.

Main Methods:

Retrospective review of six pediatric patients (aged 1-7 years) with idiopathic CG.
Analysis of clinical data, renal biopsies, serum creatinine, and estimated GFR.
Statistical comparison of renal function at presentation and follow-up, and Cox proportional hazard models for ESRD risk.

Main Results:

All patients presented with steroid-resistant nephrotic syndrome, with or without azotemia.
Median serum creatinine remained stable (1.05 to 1.25 mg/dl; p=0.128).
One complete remission, four partial remissions of proteinuria; two patients progressed to ESRD within 27 months.

Conclusions:

Collapsing glomerulopathy is an aggressive FSGS variant requiring etiological screening.
Idiopathic CG in children necessitates a trial of immunosuppressive therapy.
Close monitoring for disease progression to ESRD is crucial in pediatric idiopathic CG.