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[Association of CETP and CRP gene polymorphisms with non-valvular atrial fibrillation in Chinese Han population]

Wei-yu Yang1, Li-xin Xu, Huai-qin Zhang

  • 1Department of Cardiovascular Medicine, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325027 P. R. China.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|April 9, 2008
PubMed

Insights

Genetic variations in cholesteryl transfer protein (CETP) TaqIB and C-reactive protein (CRP) 1444C/T are linked to non-valvular atrial fibrillation in the Chinese Han population, with specific alleles acting as protective or risk factors.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Epidemiology
  • Population Genetics

Background:

  • Non-valvular atrial fibrillation (NVAF) is a common arrhythmia with complex etiology.
  • Genetic factors play a role in NVAF susceptibility.
  • Polymorphisms in genes like CETP and CRP are potential contributors to NVAF risk.

Purpose of the Study:

  • To investigate the association between CETP TaqIB and CRP 1444C/T gene polymorphisms and NVAF in the Chinese Han population.
  • To determine if specific genotypes confer protection or increase risk for NVAF.

Main Methods:

  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed.
  • Genotype distributions of CETP TaqIB and CRP 1444C/T were analyzed.
  • 147 NVAF patients and 147 controls from the Chinese Han population were studied.

Main Results:

  • Genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium.
  • Significant associations were found between CETP TaqIB and CRP 1444C/T polymorphisms and NVAF.
  • Gender-specific differences were observed, with smoking and CRP polymorphisms in females, and BMI and CETP polymorphisms in males.

Conclusions:

  • CETP TaqIB (B2 allele) may be a protective factor, while CRP 1444C/T (T allele) may be a risk factor for NVAF in this population.
  • Smoking and CRP1444T may increase hereditary susceptibility in females.
  • Obesity and CETP TaqIB may increase hereditary susceptibility in males.
Abstract

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