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Updated: Jul 6, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Polyelectrolyte-induced self-assembly of positively charged alkynylplatinum(II)-terpyridyl complexes in aqueous media
Cong Yu1, Kenneth Hoi-Yiu Chan, Keith Man-Chung Wong
1Center for Carbon-Rich Molecular and Nanoscale Metal-Based Materials Research, Department of Chemistry and HKU-CAS Joint Laboratory on New Materials, The University of Hong Kong, Hong Kong, PR China.
Abstract:
Polyelectrolytes carrying multiple negative charges were found to induce the aggregation and self-assembly of the positively charged platinum(II)-terpyridyl complexes in aqueous media. The aggregation and self-assembly of the complexes were driven by electrostatic interactions between the polymer and the complex, and by terpyridine ligand pi-pi stacking and platinum-platinum (metal-metal) interactions. As a result, remarkable UV/Vis and emission spectral changes were observed. The spectroscopic property changes were related to the structural properties of the metal complexes as well as the polyelectrolytes. The induced self-assembly of the platinum complexes was also strongly affected by the solution properties of the aqueous media, for example, the solution pH, ionic strength, and the percentage of organic solvent added.
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