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Updated: Jul 6, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Electrospun biodegradable nanofibrous mats for tissue engineering.

Albana Ndreu1, Lila Nikkola, Hanna Ylikauppila

  • 1Biotechnology Research Unit, Department of Biological Sciences, Middle East Technical University, Ankara, Turkey. ndreualbana@yahoo.com

Nanomedicine (London, England)
|April 9, 2008
PubMed
Summary

This study electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and its blends into fibrous scaffolds for bone tissue engineering. The PHBV-PLLA blend showed the most promising results for cell attachment and proliferation.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Microbial polyesters like poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) are promising for tissue engineering.
  • Electrospinning is a versatile technique for fabricating fibrous scaffolds with controlled morphology.

Purpose of the Study:

  • To fabricate and characterize PHBV and its blends into fibrous scaffolds using electrospinning for bone tissue engineering.
  • To evaluate the influence of processing parameters and polymer blends on scaffold properties and cell interactions.

Main Methods:

  • Electrospinning of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and its blends with PLLA, PLGA, and P(L,DL)LA at various concentrations.
  • Characterization of scaffold morphology, fiber diameter, and surface porosity.

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Last Updated: Jul 6, 2026

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  • In vitro cell culture studies using Saos-2 cells to assess cell growth, penetration, and attachment.
  • Surface modification using oxygen plasma treatment.

    • Main Results:

    • Fiber diameter was significantly influenced by polymer concentration, increasing with higher concentrations.
    • Blends of PHBV with lactide-based polymers resulted in more uniform fibers with fewer beads.
    • Electrospun scaffolds promoted Saos-2 cell growth and penetration, with surface modification enhancing cell spreading.
    • The PHBV-PLLA blend exhibited superior performance in supporting cell proliferation, attachment, and spreading.

    Conclusions:

    • Electrospun PHBV-based scaffolds demonstrate significant potential for bone tissue engineering applications.
    • The PHBV-PLLA blend offers the most favorable characteristics for promoting cellular response in bone regeneration.
    • Further studies are warranted to explore the full potential of these scaffolds in bone tissue engineering.