Evolution of DNA polymerase iota structure and function in eukaryotes

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A V Makarova1, V Z Tarantul, L V Gening

  • 1Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia. amakarova-img@yandex.ru

Biochemistry. Biokhimiia
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PubMed

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Replication in Eukaryotes01:29

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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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In most genes, the transcription site is a single base present upstream of the coding sequence. Though RNAP is a catalytically efficient enzyme, it does not recognize...