Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Transgenic Organisms00:53

Transgenic Organisms

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Susceptibility of Methicillin-Resistant Staphylococcus aureus to Ceftaroline: A Prospective Observational Study From a Tertiary Care Hospital in North India.

Cureus·2026
Same author

Prevalence and predictors of coeliac disease in patients with irritable bowel syndrome: A prospective study from Rajasthan, India.

Tropical doctor·2026
Same author

Accelerated Direct Identification of Gram-Positive and Gram-Negative Bacteria Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) in Critically Ill Patients.

Cureus·2026
Same author

Dual-Targeting iRGD-Functionalized Pentablock Copolymer Nanosystem for miR-345-5p and Gemcitabine Delivery to Pancreatic Tumors.

ACS applied materials & interfaces·2026
Same author

INDRA-CMIP6: Indian subcontinent high resolution Downscaled pRecipitation and Air temperature data from CMIP6.

Scientific data·2026
Same author

Visceral Muscle Dysmotility Syndrome With Esophageal Aperistalsis (VMDS Tetrad): A Rare Initial Manifestation of Systemic Lupus Erythematosus.

ACG case reports journal·2026

Related Experiment Video

Updated: Jul 6, 2026

An Efficient In Vitro Transposition Method by a Transcriptionally Regulated Sleeping Beauty System Packaged into an Integration Defective Lentiviral Vector
10:13

An Efficient In Vitro Transposition Method by a Transcriptionally Regulated Sleeping Beauty System Packaged into an Integration Defective Lentiviral Vector

Published on: January 12, 2018

Synthetic sustained gene delivery systems.

Ankit Agarwal1, Surya K Mallapragada

  • 1Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa, 50011, USA.

Current Topics in Medicinal Chemistry
|April 9, 2008
PubMed
Summary
This summary is machine-generated.

Controlled gene delivery systems offer a safer, more effective way to administer gene therapy. These systems act as depots, providing sustained therapeutic protein levels and minimizing side effects from gene escape.

More Related Videos

Production of Double-stranded DNA Ministrings
06:12

Production of Double-stranded DNA Ministrings

Published on: February 29, 2016

A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells
10:42

A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells

Published on: December 12, 2017

Related Experiment Videos

Last Updated: Jul 6, 2026

An Efficient In Vitro Transposition Method by a Transcriptionally Regulated Sleeping Beauty System Packaged into an Integration Defective Lentiviral Vector
10:13

An Efficient In Vitro Transposition Method by a Transcriptionally Regulated Sleeping Beauty System Packaged into an Integration Defective Lentiviral Vector

Published on: January 12, 2018

Production of Double-stranded DNA Ministrings
06:12

Production of Double-stranded DNA Ministrings

Published on: February 29, 2016

A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells
10:42

A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells

Published on: December 12, 2017

Area of Science:

  • Biomedical Engineering
  • Drug Delivery
  • Gene Therapy

Background:

  • Gene therapy requires safe and efficient delivery systems to avoid cytotoxicity and immune responses.
  • Current bolus gene delivery methods lead to factor loss and potential off-target effects.
  • Controlled gene delivery systems aim to provide sustained therapeutic effects and localized action.

Purpose of the Study:

  • To review novel approaches for controlled gene delivery.
  • To examine different modalities for sustained delivery of viral and non-viral gene vectors.
  • To present design parameters and release mechanisms of polymer-based systems.

Main Methods:

  • Review of existing literature on controlled gene delivery systems.
  • Analysis of DNA encapsulation in nano/micro polymer spheres.
  • Examination of DNA entrapment in hydrogels and scaffolds.

Main Results:

  • Controlled systems act as localized depots for sustained gene release.
  • These systems prolong therapeutic protein levels and limit DNA degradation.
  • Polymeric nano/micro spheres, hydrogels, and scaffolds are key platforms for controlled gene delivery.

Conclusions:

  • Controlled gene delivery systems are crucial for overcoming current gene therapy limitations.
  • Novel approaches using polymers offer promising applications for sustained gene therapy.
  • Further development in design and release mechanisms will enhance gene therapy efficacy.