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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...

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Related Experiment Video

Updated: Jul 6, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Deep brain stimulation for Parkinson's disease.

Patricia Limousin1, Irene Martinez-Torres

  • 1Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, England, United Kingdom. p.limousin@ion.ac.uk

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|April 9, 2008
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) offers surgical treatment for Parkinson's disease, targeting tremor, dyskinesias, and other symptoms. While effective, it's a symptomatic therapy with limitations, necessitating further research for improved approaches.

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Last Updated: Jul 6, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

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Published on: July 16, 2014

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
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Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Area of Science:

  • Neurosurgery
  • Neurology
  • Movement Disorders

Background:

  • Parkinson's disease (PD) management has evolved with surgical interventions.
  • Deep brain stimulation (DBS) has emerged as a significant advancement in PD treatment over the past two decades.

Purpose of the Study:

  • To review the evolution and current status of DBS targets for Parkinson's disease.
  • To compare the efficacy and limitations of different DBS targets.
  • To highlight the need for ongoing research in PD surgical treatments.

Main Methods:

  • Review of existing literature on DBS for Parkinson's disease.
  • Analysis of outcomes for thalamic, subthalamic nucleus (STN), and internal globus pallidus (GPi) targets.
  • Discussion of patient selection criteria and treatment limitations.

Main Results:

  • Thalamic DBS is effective for tremor but limited for other symptoms.
  • Subthalamic nucleus (STN) DBS improves a broader range of symptoms but may have higher morbidity.
  • Internal globus pallidus (GPi) stimulation is effective for dyskinesias.

Conclusions:

  • DBS is a valuable symptomatic treatment for select Parkinson's disease patients.
  • Target selection (thalamus, STN, GPi) depends on predominant symptoms and patient factors.
  • Current DBS techniques do not alter disease progression, underscoring the need for novel therapeutic strategies.