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Related Experiment Video

Updated: Jul 6, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep brain stimulation in Tourette's Syndrome.

Linda Ackermans1, Yasin Temel, Veerle Visser-Vandewalle

  • 1Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|April 9, 2008
PubMed
Summary

Deep brain stimulation (DBS) offers a therapeutic option for severe Tourette's Syndrome (TS) when other treatments fail. Research explores various targets within brain circuits to optimize DBS effectiveness for managing debilitating tics.

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Tourette's Syndrome (TS) is a neuropsychiatric disorder marked by motor and vocal tics, often co-occurring with behavioral issues.
  • While symptoms frequently remit in adulthood, the underlying pathophysiology of TS remains incompletely understood.
  • Existing research on cortico-basal ganglia-thalamocortical circuits offers insights into the efficacy of deep brain stimulation (DBS) for tic reduction.

Purpose of the Study:

  • To review the therapeutic potential of deep brain stimulation (DBS) for patients with severe Tourette's Syndrome (TS) refractory to conservative management.
  • To discuss the evolution and current understanding of DBS targets and their application in treating intractable TS.
  • To highlight the importance of established inclusion and exclusion criteria for patient selection in DBS therapy for TS.

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Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Related Experiment Videos

Last Updated: Jul 6, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
12:04

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Main Methods:

  • Review of literature on deep brain stimulation (DBS) for Tourette's Syndrome (TS).
  • Analysis of historical and current DBS targets, including thalamic, globus pallidus interna, and nucleus accumbens.
  • Examination of patient selection criteria for DBS in severe TS.

Main Results:

  • Deep brain stimulation (DBS) has been utilized as a treatment for intractable Tourette's Syndrome (TS) since 1999.
  • Various brain targets, such as the globus pallidus pars interna and nucleus accumbens, have been explored in small patient cohorts.
  • The development of specific inclusion and exclusion criteria aims to identify optimal candidates for DBS therapy.

Conclusions:

  • Deep brain stimulation (DBS) represents a viable therapeutic strategy for severe Tourette's Syndrome (TS) when conventional treatments are ineffective.
  • Ongoing research into DBS targets and patient selection continues to refine this advanced treatment modality.
  • Understanding the neurocircuitry involved in TS is crucial for advancing DBS efficacy and patient outcomes.