Related Experiment Video
Updated: Jul 6, 2026

Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
Interaction behaviors between chitosan and hemoglobin
1School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jinagsu, 25002, PR China.
Abstract:
The interaction and association between chitosan and hemoglobin (Hb) are studied by UV-vis and fluorescence spectroscopies, viscometry, circular dichroism, dynamic and static light scattering. Chitosan can obviously associate with Hb to form protein-chitosan complexes, which affects microstructure of Hb. The distance between the first association site of chitosan with 214-tryptophan residue in Hb is about 5.473 nm. The intrinsic UV-vis absorption and fluorescence intensities of Hb increase with an increase of chitosan concentration. The alpha-helix in Hb is drawn and changed into beta-sheet.
Related Concept Videos
Complexation Equilibria: The Chelate Effect
Hemoglobin
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Drug Binding to Blood Components
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are further...
Cooperative Allosteric Transitions

