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[ADP-induced thrombocyte aggregation in hypertension patients with different degrees of left ventricular hypertrophy]
Insights
Essential hypertension patients show increased adenosine diphosphate (ADP)-induced platelet aggregation with worsening left ventricular hypertrophy (LVH). Laser aggregometry reveals this sensitivity, outperforming the Born method.
Area of Science:
- Cardiology
- Hematology
- Biomedical Engineering
Background:
- Essential hypertension is a cardiovascular risk factor.
- Left ventricular hypertrophy (LVH) is a common complication of hypertension.
- Platelet aggregation plays a role in thrombotic events.
Purpose of the Study:
- To investigate adenosine diphosphate (ADP)-induced platelet aggregation in patients with essential hypertension and varying degrees of LVH.
- To compare the sensitivity of a new laser aggregometry method with the classic Born method.
Main Methods:
- Studied 59 patients with essential hypertension (stages I-II) and different LVH levels.
- Measured mean aggregate radius using a laser aggregation analyzer.
- Assessed left ventricular myocardial mass via echocardiography.
Main Results:
- Significant differences in ADP-induced platelet aggregation (0.5 microM ADP) were observed with increasing LVH.
- Platelet aggregation in patients without LVH did not differ from healthy volunteers.
- Laser aggregometry demonstrated higher sensitivity compared to the Born method.
Conclusions:
- LVH severity correlates with enhanced ADP-induced platelet aggregation in essential hypertension.
- Laser aggregometry is a sensitive tool for assessing platelet function in hypertensive patients.
Abstract:
Adenosine diphosphate (ADP)-induced platelet aggregation was studied in 59 patients suffering from essential hypertension, stages I and II (WHO, 1979) with different degree of left ventricular hypertrophy (LVH) by a new optical method. Using a laser aggregation analyzer the mean aggregate radius was measured in relative units. The left ventricular myocardial mass was estimated by echocardiography. Using laser aggregatograms the significant differences in aggregation responses were revealed with 0.5 microM ADP. In a group of patients without LVH, the aggregation response to 0.5 microM ADP did not differ from that in a group of healthy volunteers. With the growth of LVH from moderate to severe the response increased in succession. The same differences which were not, however, significant were observed with higher ADP concentrations. It was also found that the new method of laser aggregometry is more sensitive than the classic Born method.