Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 6, 2026

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature
09:39

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature

Published on: November 18, 2019

Capillary scale NMR flow mapping.

Walter Massefski1

  • 1Department of Chemical Technologies, Chemical and Screening Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA. wmassefski@wyeth.com <wmassefski@wyeth.com>

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|April 9, 2008
PubMed
Summary

This study introduces a simple method for direct visualization in capillary scale flow Nuclear Magnetic Resonance (NMR) systems. This technique optimizes flow rates and sampling efficiency for analyzing numerous small samples.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Palladium-peptide oxidative addition complexes for bioconjugation.

Chemical science·2022
Same author

Quantitative Interpretation of Protein Diffusion Coefficients in Mixed Protiated-Deuteriated Aqueous Solvents.

The journal of physical chemistry. B·2022
Same author

Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways.

Leukemia·2020
Same author

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

ACS chemical biology·2018
Same author

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.

Nature communications·2018
Same author

[<sup>18</sup>F]Fluorocholine and [<sup>18</sup>F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM.

Clinical cancer research : an official journal of the American Association for Cancer Research·2018

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Biophysical Chemistry

Background:

  • Traditional Nuclear Magnetic Resonance (NMR) methods face challenges in high-throughput sample analysis.
  • Capillary scale flow NMR offers advantages for examining large numbers of samples efficiently.

Purpose of the Study:

  • To present a straightforward method for direct sample visualization within capillary scale flow NMR systems.
  • To demonstrate the application of this visualization method for optimizing system parameters.

Main Methods:

  • Development and application of a simple direct visualization technique for flow cells in capillary NMR.
  • Utilizing the visualization method to determine optimal flow rates.
  • Employing the method to ascertain optimal sampling efficiency for small sample volumes.

More Related Videos

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
06:56

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

Published on: January 7, 2021

Related Experiment Videos

Last Updated: Jul 6, 2026

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature
09:39

Spatial Temporal Analysis of Fieldwise Flow in Microvasculature

Published on: November 18, 2019

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation
06:56

Human Fetal Blood Flow Quantification with Magnetic Resonance Imaging and Motion Compensation

Published on: January 7, 2021

Main Results:

  • Successful implementation of direct sample visualization in capillary flow NMR.
  • Demonstrated ability to measure and optimize flow rates for enhanced performance.
  • Established a method for determining optimal sampling efficiency, particularly for small sample sizes.

Conclusions:

  • Direct visualization is a valuable tool for optimizing capillary scale flow NMR systems.
  • This method facilitates efficient analysis of numerous small samples by tuning flow and sampling parameters.
  • The technique enhances the practicality and efficiency of flow NMR for high-throughput applications.