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Updated: May 6, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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A SNO storm in skeletal muscle

Jonathan S Stamler1, Qi-An Sun, Douglas T Hess

  • 1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. staml001@mc.duke.edu

Cell
|April 9, 2008
PubMed
Summary

Hyper-S-nitrosylation of the ryanodine receptor calcium release channel (RyR1) in skeletal muscle disrupts calcium flow. This finding explains muscle dysfunction in strenuous exercise and congenital disorders like malignant hyperthermia.

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