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Updated: May 6, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
A SNO storm in skeletal muscle
Jonathan S Stamler1, Qi-An Sun, Douglas T Hess
1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. staml001@mc.duke.edu
Abstract:
Dysregulated S-nitrosylation of proteins characterizes a broad array of human disorders, but its role in disease etiology is not well understood. Two new studies (Durham et al., 2008; Bellinger et al., 2008) now show that hyper-S-nitrosylation of the ryanodine receptor calcium release channel (RyR1) in skeletal muscle disrupts calcium ion flux. This disruption underlies the impaired contractility and cellular damage of skeletal muscle during strenuous exercise and in a spectrum of congenital muscle disorders including malignant hyperthermia.
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