Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

AR, apoE, and cognitive function.

Jacob Raber1

  • 1Department of Behavioral Neuroscience, Division of Neuroscience, ONPRC, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. raberj@ohsu.edu

Hormones and Behavior
|April 9, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mild Neonatal Hypoxia Targets Synaptic Maturation, Disrupts Adult Hippocampal Learning and Memory, and Is Associated with CK2-Mediated Loss of Synaptic Calcium-Activated Potassium Channel KCNN2 Activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework.

Frontiers in aging neuroscience·2026
Same author

Diet-Microbiome Relationships in Prostate-Cancer Survivors with Prior Androgen Deprivation-Therapy Exposure and Previous Exercise Intervention Enrollment.

Microorganisms·2026
Same author

Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer's disease App<sup>NL-G-F</sup> knock-in mouse model.

Scientific reports·2025
Same author

Exercise, APOE Genotype, and Testosterone Modulate Gut Microbiome-Cognition Associations in Prostate Cancer Survivors.

Genes·2025
Same author

The Christchurch point mutation in mouse APOE reduces Aβ-induced tau and α-synuclein pathologies.

bioRxiv : the preprint server for biology·2025
Same journal

Timed melatonin administration increases territorial but not non-territorial aggression in female Siberian hamsters.

Hormones and behavior·2026
Same journal

Neuroendocrine signatures of urban aggression: Arginine vasotocin (AVT) receptor distribution and expression in male song sparrow (Melospzia melodia) brain.

Hormones and behavior·2026
Same journal

Hormones, sex differences, and autism: From single-cause theories to integrated developmental systems.

Hormones and behavior·2026
Same journal

Androgen receptor activation is involved in maintaining goal-directed behavior in levonorgestrel-treated female rats.

Hormones and behavior·2026
Same journal

Sleep hygiene behaviors and actigraphic sleep: a pilot analysis of gender differences.

Hormones and behavior·2026
Same journal

Neuroendocrine basis of affective behavior: what we can learn from differences in sex development (DSD).

Hormones and behavior·2026
See all related articles

Lower androgen levels may increase the risk of cognitive decline and Alzheimer's disease (AD) in aging individuals. This review explores the beneficial roles of androgens and their receptors, including potential interactions with apolipoprotein E4.

Area of Science:

  • Neuroendocrinology
  • Gerontology
  • Alzheimer's Disease Research

Background:

  • Androgen deficiency is increasingly recognized as a potential risk factor for age-related cognitive decline and Alzheimer's disease (AD).
  • Hormone replacement therapies, including estrogen for women and testosterone for men, are under investigation for their potential neuroprotective effects.
  • Androgen receptors (ARs) play a crucial role in mediating the effects of androgens in the central nervous system.

Purpose of the Study:

  • To review the potential beneficial effects of androgens and androgen receptors (ARs) on cognitive function in both males and females.
  • To discuss the proposed interaction between the androgen receptor (AR) and apolipoprotein E4 (apoE4), a known genetic risk factor for AD.
  • To explore the implications of this AR-apoE4 interaction for age-related cognitive decline and AD pathogenesis.

Related Experiment Videos

Main Methods:

  • Literature review of existing studies on androgens, cognitive function, and Alzheimer's disease.
  • Analysis of preclinical and clinical data investigating androgen and estrogen therapies.
  • Examination of molecular mechanisms underlying androgen receptor signaling and its potential interplay with apolipoprotein E.

Main Results:

  • Androgens and AR signaling show potential neuroprotective effects relevant to cognitive health in aging.
  • Evidence suggests a possible interaction between AR and apoE4, which may influence AD risk and progression.
  • Clinical trials are ongoing to validate the therapeutic potential of androgen-related interventions.

Conclusions:

  • Androgens and their receptors represent a promising therapeutic target for mitigating age-related cognitive decline and AD.
  • Further research into the AR-apoE4 interaction is warranted to elucidate its role in AD pathogenesis.
  • Personalized therapeutic strategies targeting androgen pathways may benefit individuals at risk for cognitive impairment.