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Updated: Jul 6, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Muscle atrophy associated with multiple sclerosis: a benign condition or the onset of amyotrophic lateral sclerosis?
Jeffrey A Allen1, Robert Stein, Richard A Baker
1Department of Neurology, Tufts University, Boston, MA, USA. jeffallen@rcn.com
Abstract:
When muscular atrophy develops in multiple sclerosis (MS) patients, its etiology may vary from benign to serious. We describe an individual with a 24-year history of MS who developed amyotrophic lateral sclerosis (ALS). The literature is reviewed with particular attention to the clinical and electrophysiologic characteristics of patients with MS and muscular atrophy and to those rare patients with concurrent MS and ALS. Circumstances warranting a heightened suspicion for concurrent ALS are discussed and careful evaluation of similar patients is encouraged.
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