Seborrheic inclusion cyst

Area of Science:

• Dermatology
• Pathology
• Surgical Oncology

Background:

• Epidermoid cysts are common benign skin tumors.
• A rare variant, epidermoid cysts with seborrheic keratosis-like linings, has been recently described.
• The etiology and typical presentation of this variant remain under investigation.

Observation:

• A patient presented with a cyst exhibiting features of both epidermoid cyst and seborrheic keratosis.
• This specific cyst developed subsequent to the complete excision of a pre-existing, histologically confirmed seborrheic keratosis.
• The cyst lining mimicked features typically seen in seborrheic keratosis, presenting a diagnostic challenge.

Findings:

• Histopathological examination confirmed the presence of an epidermoid cyst with atypical lining cells resembling those of a seborrheic keratosis.
• The findings suggest a potential link between prior seborrheic keratosis excision and the development of this rare cyst variant.
• This represents a novel observation of post-surgical cyst formation with specific histological characteristics.

Implications:

• This case expands the understanding of epidermoid cyst variants and their potential development pathways.
• It suggests that surgical trauma or altered tissue environment following seborrheic keratosis excision may predispose to the formation of these unique cysts.
• Further research is warranted to elucidate the precise mechanisms and clinical significance of epidermoid cysts with seborrheic keratosis-like linings.