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Spontaneous alternation behavior: an animal model for obsessive-compulsive disorder?
E Yadin1, E Friedman, W H Bridger
1Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129.
Pharmacology, Biochemistry, and Behavior
|October 1, 1991
Summary
This study explored spontaneous alternation in rats as an animal model for obsessive-compulsive disorder (OCD). Serotonin system manipulation affected behavior, suggesting a link to OCD symptoms like indecisiveness.
Area of Science:
- Neuroscience
- Behavioral Science
- Pharmacology
Background:
- Obsessive-compulsive disorder (OCD) presents with perseverative symptoms and indecisiveness.
- Spontaneous alternation is a well-established behavioral paradigm in rodents.
Purpose of the Study:
- To investigate spontaneous alternation as a potential animal model for OCD symptoms.
- To examine the effects of serotonergic system manipulation on spontaneous alternation behavior.
Main Methods:
- Rats were trained in a T-maze to assess spontaneous alternation.
- The effects of serotonin agonists (5-MeODMT, 8-OH-DPAT) and fluoxetine on alternation were evaluated.
Main Results:
- Both 5-HT agonists significantly disrupted spontaneous alternation.
- Chronic fluoxetine treatment demonstrated a protective effect against 5-MeODMT-induced disruption.
Conclusions:
- Serotonergic modulation of spontaneous alternation may serve as a valid animal model for OCD-related perseverative behaviors.
- This model could aid in understanding and treating OCD symptoms.