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Updated: Jul 6, 2026

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
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Optimized translation of microbubbles driven by acoustic fields.

Jean O Toilliez1, Andrew J Szeri

  • 1Department of Mechanical Engineering, University of California at Berkeley, Berkeley, California 94720, USA.

The Journal of the Acoustical Society of America
|April 10, 2008
PubMed
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This summary is machine-generated.

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This study optimizes acoustic bubble manipulation for enhanced translation. Novel acoustic waveforms significantly amplify bubble movement at sub-resonant frequencies, offering new possibilities for applications like targeted drug delivery.

Area of Science:

  • Fluid dynamics
  • Acoustics
  • Nonlinear dynamics

Background:

  • Acoustically driven bubbles exhibit complex translation dynamics.
  • Understanding bubble movement is crucial for applications like targeted drug delivery.

Purpose of the Study:

  • To derive a closed-form solution for unsteady bubble translation.
  • To design optimal acoustic forcing for maximized bubble displacement.
  • To explore bubble behavior across various acoustic intensities and frequencies.

Main Methods:

  • Analysis of the bubble translation equation with inverse Reynolds number as a perturbation parameter.
  • Utilizing the Rayleigh-Plesset equation for optimal acoustic forcing design.
  • Investigating nonlinear radial oscillations and pressure fields.

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Published on: June 12, 2021

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Main Results:

  • A leading-order solution for bubble translation was obtained.
  • Optimized acoustic waveforms significantly enhance bubble displacement at sub-resonant frequencies.
  • Sinusoidal forcing is near-optimal at resonant and super-resonant frequencies.

Conclusions:

  • Non-sinusoidal acoustic forcing can dramatically improve bubble translation.
  • Findings suggest new methods for predicting acoustic radiation force effects.
  • Potential applications include targeted drug delivery, selective bubble manipulation, and accumulation.