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Lp(a) lipoprotein level and longevity.

K Berg1, O C Rø

  • 1Institute of Medical Genetics, University of Oslo, Norway.

Annales De Genetique
|January 1, 1991
PubMed
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High levels of Lipoprotein(a) (Lp(a)) are a risk factor for heart disease. This study found fewer older adults with high Lp(a) levels, suggesting it may impact longevity.

Area of Science:

  • Cardiovascular Science
  • Genetics
  • Gerontology

Background:

  • Lipoprotein(a) (Lp(a)) is a genetically determined serum lipoprotein.
  • Elevated Lp(a) levels are a known risk factor for atherosclerotic diseases, including coronary heart disease (CHD).
  • Cardiovascular disease is a leading cause of mortality worldwide.

Purpose of the Study:

  • To investigate Lp(a) lipoprotein levels in a cohort of very old individuals (≥83 years) with preserved physical and mental capacities.
  • To determine if high Lp(a) levels are underrepresented in a population of 'successful agers'.

Main Methods:

  • Blood samples were analyzed for Lp(a) lipoprotein levels.
  • The study group comprised 102 individuals aged 83 and older, selected from a larger cohort for their good health.

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  • Lp(a) levels were compared to the general population's 75th percentile.

    • Main Results:

    • A significant shortage of individuals with Lp(a) levels above the 75th percentile was observed in the 'successful aging' group.
    • The highest Lp(a) level in the study group corresponded to the 88th percentile of the general population.
    • These findings were unlikely due to chance or a decline in Lp(a) levels over time.

    Conclusions:

    • High Lp(a) lipoprotein levels may be associated with reduced lifespan.
    • Individuals with high Lp(a) may be less likely to reach advanced age with preserved cognitive and physical function.
    • This suggests a potential role for Lp(a) in mortality risk, particularly concerning cardiovascular health in aging populations.