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Updated: Jul 6, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Fulminant autoimmune hepatitis after successful interferon treatment in an HIV-HCV co-infected patient
Romain Coriat1, Philippe Podevin
1Service d'Hépatogastroentérologie, Hôpital Cochin, 27 rue du faubourg Saint-Jacques, Paris, France. romain.coriat@cch.ap-hop-paris.fr
Abstract:
Hepatitis C (HCV) treatment using interferon-alpha (IFN-alpha) and ribavirin is recommended in HIV/HCV co-infected patients to prevent liver cirrhosis and liver-related death. However, in addition to its antiviral activity, IFN is a pleiotropic cytokine able to synergistically amplify T-cell autoreactivity. Here, we report for the first time the induction of a subfulminant autoimmune hepatitis (AIH) after four months of a successful treatment of HCV-1b infection using peg-IFN and ribavirin, in a 48-year-old woman co-infected with HIV. Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.
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