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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.4K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.2K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.1K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Related Experiment Video

Updated: Jan 9, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Notch in the niche.

Martin Gering1, Roger Patient

  • 1Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.

Cell Stem Cell
|April 10, 2008
PubMed
Summary
This summary is machine-generated.

Notch signaling is crucial for embryonic hematopoietic stem cell (HSC) development. New research shows that inactivating the Notch pathway in mature HSCs does not hinder their self-renewal capabilities.

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Related Experiment Videos

Last Updated: Jan 9, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Developmental Biology

Background:

  • Notch signaling is recognized as vital for hematopoietic stem cell (HSC) generation during embryonic development.
  • Previous understanding suggested Notch pathway involvement in HSC maintenance.

Discussion:

  • This study challenges the established view by investigating the role of Notch signaling in HSC self-renewal.
  • The research focuses on the consequences of Notch pathway inactivation specifically within HSCs.

Key Insights:

  • Maillard et al. (2008) provide strong evidence that Notch pathway inactivation in HSCs does not impede their self-renewal capacity.
  • This finding suggests a potentially distinct role for Notch signaling in HSC formation versus maintenance.

Outlook:

  • Further research is warranted to fully elucidate the specific mechanisms governing HSC self-renewal independent of Notch signaling.
  • Understanding these pathways is critical for regenerative medicine and treating blood disorders.