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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

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Published on: December 13, 2019

Adiponectin and left ventricular structure and function in healthy adults.

Michaela Kozakova¹, Elza Muscelli, Allan Flyvbjerg

¹Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy. m.kozakova@int.med.unipi.it

The Journal of Clinical Endocrinology and Metabolism

|April 10, 2008

Summary

Adiponectin, particularly its high-molecular-weight form, is linked to left ventricular wall thickness and diastolic function in healthy individuals, independent of metabolic factors. This finding highlights adiponectin's role in maintaining cardiac structure and function.

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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

Cardiology
Endocrinology
Metabolic Research

Background:

Adiponectin, a hormone, inhibits protein synthesis in heart cells, counteracting effects of workload and insulin on left ventricular (LV) mass and wall thickness (WT).
Understanding adiponectin's role in cardiac structure and function, independent of metabolic influences, is crucial for cardiovascular health.

Purpose of the Study:

To investigate the relationship between adiponectin and its isoforms with LV mass, WT, and function.
To determine if these relationships persist independently of established metabolic factors like insulin sensitivity.

Main Methods:

A cross-sectional study involving 77 healthy volunteers (42 men, aged 30-59).
Assessment of insulin sensitivity via oral glucose tolerance test and euglycemic hyperinsulinemic clamp.
Echocardiography and tissue Doppler imaging for LV structure and function; plasma adiponectin levels (total and isoforms) were measured.

Main Results:

Plasma adiponectin was an independent correlate of LV wall thickness (WT) and LV longitudinal late diastolic velocity.
High-molecular-weight adiponectin, but not other isoforms or insulin sensitivity, showed an inverse relationship with WT and diastolic function.
Multivariate analysis identified sex, BMI, stroke work, and smoking as independent factors for LV mass.

Conclusions:

Circulating total and high-molecular-weight adiponectin are independently associated with LV wall thickness and diastolic function in healthy individuals.
These associations are independent of age and metabolic factors, suggesting a direct role for adiponectin in cardiac remodeling and function.
The findings emphasize the importance of adiponectin in preserving cardiac health beyond its metabolic effects.