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Kidney function decline and physical function in women.

Julie Lin1, Gary C Curhan

  • 1Renal Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. jlin11@partners.org

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|April 10, 2008
PubMed
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A significant decline in estimated glomerular filtration rate (eGFR) over 11 years is linked to reduced physical function in women. This kidney function decline is independently associated with lower physical function scores.

Area of Science:

  • Nephrology
  • Gerontology
  • Epidemiology

Background:

  • Kidney dysfunction is associated with impaired quality of life.
  • Limited data exist on the relationship between kidney function decline and physical function.

Purpose of the Study:

  • To investigate the association between kidney function decline and physical function in women.
  • To determine if a decline in estimated glomerular filtration rate (eGFR) impacts physical function.

Main Methods:

  • Study included 2544 women from the Nurses' Health Study.
  • eGFR was estimated using the four-variable MDRD equation from plasma creatinine (1989-2000).
  • Physical function was assessed using the SF-36 Physical Function Sub-Scale (PFS) in 2000.

Main Results:

Related Experiment Videos

  • A decline of >=25% in eGFR was observed in 16.8% of women.
  • Women with >=25% eGFR decline had significantly lower median PFS scores (80 vs. 85, P < 0.001).
  • eGFR decline was independently associated with a 3.5-point lower PFS score and increased odds of being in the lowest quartile of physical function.

Conclusions:

  • An eGFR decline of >=25% over 11 years is independently associated with lower physical function in women.
  • This finding highlights the impact of kidney function on physical well-being.