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5-HT1A-agonistic properties of naftopidil, a novel antihypertensive drug
H O Borbe1, P Metzenauer, I Szelenyi
1ASTA Pharma AG, Department of Biochemistry, Frankfurt/Main, F.R.G.
European Journal of Pharmacology
|November 19, 1991
Abstract:
Naftopidil, a novel antihypertensive compound, possesses 5-HT1A agonistic properties in addition to being an alpha 1-adrenoceptor antagonist. The IC50 values for alpha 1-adrenoceptors (235 nmol/l) and for 5-HT1A receptors (108 nmol/l) lie in the same concentration range. The reduction in blood pressure of anesthetized cats by 8-OH-DPAT and urapidil was completely abolished by spiroxatrine, a 5-HT1A antagonist. However, the decreases in blood pressure induced by naftopidil were only partly antagonized by spiroxatrine.