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Factor VII, blood lipids and fat intake: gene-nutrient interaction and risk of coronary heart disease with the factor

R Bowman1, A M C P Joosen, A A Welch

  • 1MRC Dunn Human Nutrition Unit, Cambridge, UK.

European Journal of Clinical Nutrition
|April 10, 2008
PubMed

Insights

Dietary fat intake impacts factor VII coagulant activity (FVIIc) in women, while blood lipids affect FVIIc in both genders. The R353Q gene variant had minimal influence on these associations, though it modified the triacylglycerol-FVIIc link in men.

Area of Science:

  • Cardiovascular epidemiology
  • Nutritional science
  • Human genetics

Background:

  • Investigated the relationship between dietary fat, blood lipids, factor VII coagulant activity (FVIIc), and coronary heart disease (CHD) risk.
  • Assessed the influence of the factor VII gene R353Q polymorphism on these associations.

Purpose of the Study:

  • To determine how dietary fat and blood lipid levels relate to FVIIc.
  • To examine the role of the FVII R353Q polymorphism in modulating these relationships and CHD risk.

Main Methods:

  • Cross-sectional analysis of 15,073 participants from the EPIC-Norfolk study.
  • Nested case-control study including 985 CHD cases and 2009 controls.
  • Genotyping for the FVII R353Q polymorphism.

Main Results:

  • FVIIc associated with total fat intake in women, particularly RR homozygotes.
  • FVIIc positively correlated with total cholesterol and triacylglycerol in both genders.
  • The R353Q genotype showed a significant interaction with triacylglycerol levels in males.
  • No significant effect of genotype on incident CHD risk was observed.

Conclusions:

  • Dietary fat intake is strongly linked to FVIIc in women; serum lipids are linked in both genders.
  • The R353Q genotype has a minor impact on dietary fat modulation of FVIIc.
  • The association between triacylglycerol and FVIIc is stronger in males carrying the Q allele.
Abstract

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