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Updated: Jul 6, 2026
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes
Sofia I Pascu1, Philip A Waghorn, Timothy D Conry
1Chemistry Department, University of Bath, Claverton Down, UKBA2 7AY. s.pascu@bath.ac.uk
Dalton Transactions (Cambridge, England : 2003)
|April 10, 2008
Abstract:
We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.
