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Published on: December 17, 2019
Immunotherapeutic approaches in chronic myelogenous leukemia
François Guilhot1, Lydia Roy, Pierre-Jean Saulnier
1Department of Oncology-Haematology and Cell Therapy, EA 3805 and Clinical Research Centre, CHU de Poitiers, Poitiers, France. f.guilhot@chu-poitiers.fr
Abstract:
Chronic myeloid leukemia (CML) is a stem cell disease in which BCR/ABL plays an important role as oncoprotein and also as a molecular and immunogenic target. In fact, several molecular targeted drugs and immunotherapies have been developed for this disease. In the current article, several immunotherapeutic approaches in CML, including interferon-alpha and vaccination, are discussed along with results from clinical trials and the value of such immunotherapies in the imatinib-era.
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