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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

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[Beta-blockers and electroconvulsive therapy: a review]

W W van den Broek1, T H N Groenland, P G H Mulder

  • 1afdeling Psychiatrie, Erasmus mc, Postbus 2040, 3000 CA Rotterdam. w.w.vandenbroek@erasmusmc.nl.

Tijdschrift Voor Psychiatrie
|April 10, 2008
PubMed

Insights

Beta-blockers like esmolol can manage cardiovascular issues during electroconvulsive therapy (ECT). Esmolol may shorten seizure duration, with effects depending on dosage, and is recommended for patients with cardiovascular risks.

Area of Science:

  • Cardiovascular Pharmacology
  • Neuroscience
  • Anesthesiology

Context:

  • Patients with cardiovascular disorders undergoing electroconvulsive therapy (ECT) often require management for tachycardia and hypertension.
  • The use of beta-adrenergic blocking agents during ECT is a critical consideration for patient safety and treatment efficacy.

Purpose:

  • To review the effects of beta-blockers on seizure duration and cardiovascular parameters in patients undergoing ECT.
  • To identify optimal beta-blocker choices for ECT administration in patients with and without cardiovascular risk factors.

Summary:

  • A systematic search identified randomized placebo-controlled trials investigating beta-blockers in ECT.
  • Esmolol was frequently used, showing potential to shorten seizure duration in a dose-dependent manner.
  • Bilateral electrode placement and pre-seizure esmolol administration are advised for at-risk patients.

Impact:

  • Esmolol is identified as a preferred beta-blocker for ECT, particularly for managing cardiovascular responses.
  • Labetalol presents an alternative, though its longer half-life is a drawback.
  • Landiolol shows promise as a future alternative due to its favorable pharmacokinetic and pharmacodynamic profile.
Abstract

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