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Updated: Jul 6, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment
Elena Gaggelli1, Zbigniew Grzonka, Henryk Kozłowski
1Department of Chemistry, University of Siena, via Aldo Moro, 53100 Siena, Italy.
Abstract:
The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.
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